274 papers
This study identifies hypoxia-induced Scleraxis a as a critical regulator that directs epicardial progenitor cells to differentiate into a unique, vascular-stabilizing perivascular cell type (Epi-PMCs) via the Col18a1a-endostatin axis, thereby governing coronary vessel development and heart regeneration.
This study establishes a conserved regulatory network in human and Xenopus cardiogenesis where the transcription factor GATA4 directly activates TBX2 and represses PRDM1 to ensure proper cardiomyocyte differentiation, prevent alternative cell fates, and maintain functional cardiac structure.
This study utilizes Visium HD spatial transcriptomics to map the developing mouse ovary across eight timepoints, revealing a novel medullary core domain containing pre-granulosa cells that are molecularly primed for postnatal activation while still in the fetal environment.
This study reveals that Wnt proteins from both the cochlear epithelium and surrounding periotic mesenchyme act redundantly as global instructive cues to direct cochlear outgrowth and planar cell polarity, ensuring a fail-safe developmental program through epithelial-mesenchymal crosstalk.
This study demonstrates that a newly derived causal model, fitted within a Bayesian framework, can accurately estimate population-mean growth trajectories from sparse and age-uncertain measurements, offering a valuable tool for comparing growth across contemporary and historical populations despite logistical limitations.
This study reveals that the Kindlin-2-Moesin interaction regulates sprouting angiogenesis by maintaining optimal endothelial membrane tension to facilitate VEGFR2 endocytosis and signaling, offering a potential therapeutic target for neovascular diseases.
This study reveals that the transcription factor Prox1 acts as a mitotic bookmark in mouse hippocampal neural stem cells by retaining on chromatin during division to ensure the timely restoration of H3K27me3 repression on alternative lineage genes, thereby preserving dentate gyrus neuronal identity and preventing developmental defects.
This study establishes that tissue non-specific alkaline phosphatase (TNAP) and PHOSPHO1 function synergistically to control postnatal bone mineralisation in mice, where their dual deletion causes severe mineralisation failure and skeletal deformities, while a single functional TNAP allele is sufficient to rescue biomineralisation despite persistent structural abnormalities.
This study reveals that Notch-mediated fate asymmetry in zebrafish hair cells drives coordinated, opposite-directional migrations to establish proper positioning and polarity, a process regulated by the fate-specific kinase stk32a which also uncovers a hidden chiral bias in cell-pair rotations.
This study reveals that adult zebrafish spinal cord regeneration does not simply recapitulate embryonic development, but instead repurposes developmental pathways by utilizing a distinct set of adult molecular programs and progenitor identities to achieve functional recovery.
This study presents a comprehensive single-cell transcriptomic atlas of zebrafish inner ear development, identifying distinct cell states, novel molecular markers, and conserved mechanisms that govern the morphogenesis of sensory patches, semicircular canals, and the endolymphatic sac.
This study demonstrates that collective migration acts as a global symmetry-breaking cue to initiate planar cell polarity in engineered epithelial tissues by driving front-back CELSR enrichment independently of reciprocal VANGL-FZD interactions.
This study reveals that VEGF signaling acts as a physiological brake that suppresses flow-driven arterial specification by inhibiting Sox17 activity, thereby ensuring that angiogenesis and arterial patterning occur in a spatiotemporally coordinated manner during postnatal vascular morphogenesis.
This study reveals that the reproductive success of male germ cells is determined by a highly skewed, early stochastic bottleneck during embryonic migration that establishes stable clonal contributions, while the spatial compartmentalization of these clones within seminiferous tubules preserves diversity and prevents the unchecked expansion of advantageous clones.
This paper introduces LineageMap, a novel hybrid probabilistic algorithm that integrates spatial locations, gene expression profiles, and lineage barcodes from single-cell data to accurately reconstruct high-resolution cell lineage trees and infer ancestral cell states and locations, outperforming existing methods in both simulated and experimental datasets.
This study introduces the Unified Transcriptome and Mechanics Map (UTMM), a novel method that simultaneously quantifies spatial transcriptomes and cytoplasmic stiffness in intact mammalian preimplantation embryos, revealing that coordinated softening and transcriptional changes are essential for early lineage specification and embryonic progression.
This study demonstrates that in *C. elegans* seam cells, the histone deacetylase HDA-1 (homologous to mammalian HDAC1/2) orients asymmetric division polarity by repressing Wnt receptors lin-17 and cam-1 to maintain their opposing expression gradients, thereby ensuring proper cellular asymmetry.
This study demonstrates that in the *Drosophila* male germline, the paradox of maintaining stem cell potential while exhibiting distinct cellular identities is resolved through the inheritance of perdurant mRNAs and the combinatorial activation of Bmp and Jak-Stat niche signals, which together enable a pool of differentiating progeny to retain the capacity for dedifferentiation and tissue regeneration without causing stem cell overproduction.
This study reveals that sharp cell-type boundaries emerge from the temporal coordination of Wnt and Hedgehog signaling, where their alignment compresses transitional states by synchronizing cell-cycle exit with differentiation, while misalignment leads to fuzzy borders.
This study demonstrates that the transient mucin-like protein DPY-6 acts as a structural blueprint during *C. elegans* molts, guiding the periodic assembly of the apical extracellular matrix by facilitating the secretion and pattern replication of cleaved furrow collagens.