216 papers
Developmental biology explores the incredible journey of how a single cell transforms into a complex, living organism. This field investigates the molecular switches and cellular conversations that guide growth, tissue formation, and the emergence of unique body structures, helping us understand both the origins of life and the roots of developmental disorders.
At Gist.Science, we ensure you never miss a breakthrough by processing every new preprint in this category from bioRxiv. Our team provides both plain-language explanations and detailed technical summaries for each paper, making cutting-edge research accessible to everyone regardless of their scientific background.
Below are the latest studies in developmental biology, offering fresh insights into how life takes shape.
This study elucidates how the adaptor Dlish, palmitoylated by Approximated, mediates the Fat-Dachsous signaling pathway by tethering Dachs to the cortex and coupling it to opposing stabilization and destabilization effects from Ds and Fat, respectively, while protecting Dlish from degradation.
This study establishes a human pluripotent stem cell-based platform for generating bipotent hindlimb and genital tubercle progenitors by defining the specific roles of WNT, FGF, BMP, and retinoic acid signaling in their differentiation and demonstrating their developmental potency through self-organization and xenografting.
This study demonstrates that the enzyme 11β-HSD2 buffers acute maternal glucocorticoid surges to prevent premature Per1 expression and protect the segmentation clock, thereby revealing that the delayed emergence of the fetal circadian clock is an actively regulated mechanism essential for preserving embryonic development under maternal stress.
This study demonstrates that glucose regulates trophectoderm differentiation in bovine embryos through the hexosamine biosynthetic and pentose phosphate pathways via Hippo signaling, rather than through glycolysis, without affecting the inner cell mass.
This study utilizes patient-derived iPSC cartilage organoids to demonstrate that the COG4 mutation underlying Saul-Wilson syndrome disrupts ECM glycosylation and chondrogenic commitment, leading to defective cartilage formation and impaired skeletal growth.
This study demonstrates that gestational exposure to low-level environmental chemical mixtures in an outbred sheep model induces widespread, sex-specific, and lineage-dependent epigenetic changes that persist intergenerationally but face challenges in distinguishing true transgenerational inheritance from genetically regulated methylation variation.
By utilizing 3D imaging and genetic perturbations, this study reveals that the mouse placenta invades uterine spiral arteries more extensively than previously recognized and that disrupting early CXCL12-CXCR4 signaling leads to excessive trophoblast invasion mimicking human placenta accreta, thereby establishing the mouse as a superior model for studying balanced uteroplacental development.
This study develops a fluorescent dauer reporter in *Caenorhabditis inopinata* to enable comparative analysis, revealing that the molecular mechanisms governing dauer induction differ significantly between this species and the model organism *C. elegans*.
Using human induced pluripotent stem cell-derived retinal organoids, this study identifies a conserved wave of programmed retinal ganglion cell death occurring at week 8 of differentiation, which is mediated by the extrinsic apoptotic pathway via caspase 8 activation.
This study identifies the developmental regulator WT1 as a critical, isoform-tuned mechanism that drives lineage bias during the transition from naive to formative pluripotency by overriding naive networks and activating distinct anterior and posterior transcriptional programmes conserved across species.